E-PROBCONS: Enhanced PROBCONS for Multiple Sequence Alignment
نویسندگان
چکیده
منابع مشابه
Multiple sequence alignment using Probcons and Probalign.
Sequence alignment remains a fundamental task in bioinformatics. The literature contains programs that employ a host of exact and heuristic strategies available in computer science. Probcons was the first program to construct maximum expected accuracy sequence alignments with hidden Markov models and at the time of its publication achieved the highest accuracies on standard protein multiple ali...
متن کاملProbCons: Probabilistic consistency-based multiple sequence alignment.
To study gene evolution across a wide range of organisms, biologists need accurate tools for multiple sequence alignment of protein families. Obtaining accurate alignments, however, is a difficult computational problem because of not only the high computational cost but also the lack of proper objective functions for measuring alignment quality. In this paper, we introduce probabilistic consist...
متن کاملPROBCONS: Probabilistic Consistency-Based Multiple Alignment of Amino Acid Sequences
Obtaining an accurate multiple alignment of protein sequences is a difficult computational problem for which many heuristic techniques sacrifice optimality to achieve reasonable running times. The most commonly used heuristic is progressive alignment, which merges sequences into a multiple alignment by pairwise comparisons along the nodes of a guide tree. To improve accuracy, consistency-based ...
متن کاملMultiple Sequence Alignment Multiple Sequence Alignment
An algorithm for progressive multiple alignment of sequences with insertions " , 1. Introduction The problem of sequence alignment is to find the patterns of sequence conservation and similarity between pairs or sets of given sequences. In biological contexts, similarity between biological sequences usually amounts to either functional or structural similarities or divergence from a common ance...
متن کاملStrategies for multiple sequence alignment.
We present an overview of multiple sequence alignments to outline the practical consequences for the choices among different techniques and parameters. We begin with a discussion of the scoring methods for quantifying the quality of a multiple sequence alignment, followed by a discussion of the algorithms implemented within a variety of multiple sequence alignment programs. We also discuss addi...
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ژورنال
عنوان ژورنال: IJCI. International Journal of Computers and Information
سال: 2020
ISSN: 1687-7853
DOI: 10.21608/ijci.2020.15523.1002